Facile Time-Controlled Synthesis of Two-Dimensional Zr-Perylenediimide MOF Nanosheets for Ultrasensitive DNA Fluorescent Biosensing

IF 3.3 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Dalton Transactions Pub Date : 2025-09-17 DOI:10.1039/d5dt01883h

Shiyang He, Yuhong Chen, Jiayi Wang, Xiaoyang Guo, Xiangrong Pan, Yumeng Su, Xiaoyan Lu, Zhan Zhou, Lufang Ma

引用次数: 0

Abstract

This study demonstrates a facile, surfactant-free strategy for synthesizing uniform two-dimensional (2D) rhombic Zr-PDI (perylenediimide) metal-organic framework (MOF) nanosheets (NSs) (~17 nm thick) by precisely controlling the solvothermal reaction time to 6 h. Leveraging their superior fluorescence quenching capability and selectivity compared to bulk PDI crystals, we developed a Zr-PDI NSs-based fluorescent biosensor. This sensor achieved sensitive target DNA detection (limit of detection: 166 pM) and effectively discriminated single-base mismatched DNA from random DNA sequences. This work establishes a new paradigm for the synthesis of 2D MOFs and paves the way for highly sensitive biosensing platforms.

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用于超灵敏DNA荧光生物传感的二维zr -苝酰亚胺MOF纳米片的快速时间控制合成

本研究通过精确控制溶剂热反应时间至6小时，展示了一种简单、无表面活性剂的合成均匀二维（~17 nm）斜方晶型Zr-PDI（苝二酰亚胺）金属有机框架（MOF）纳米片（NSs）的策略。利用其与体PDI晶体相比优越的荧光猝灭能力和选择性，我们开发了一种基于Zr-PDI NSs的荧光生物传感器。该传感器实现了灵敏的靶DNA检测（检测限为166 pM），并能有效地从随机DNA序列中区分出单碱基错配DNA。这项工作为二维mof的合成建立了一个新的范例，为高灵敏度的生物传感平台铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dalton Transactions 化学-无机化学与核化学

CiteScore

6.60

自引率

7.50%

发文量

1832

审稿时长

1.5 months

期刊介绍： Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.