Risk factors of incidental thyroid abnormalities identified on low-dose chest CT scans in Department of Energy workers.

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Journal of occupational and environmental medicine Pub Date : 2025-09-15 DOI:10.1097/JOM.0000000000003547

Khaula Khatlani, Steven Markowitz, Mark Griffon, Amy Manowitz, Jennifer Stuckey, Yan Guo, Albert Miller, Jeffrey A Miller, Maaike van Gerwen

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Abstract

Objective: We evaluated risk factors of thyroid abnormalities detected on low-dose CT (LDCT) among nuclear weapons workers in a lung cancer screening program.

Methods: We conducted a matched case-control study of participants with (647 cases) and without (1941 controls) incidental thyroid abnormalities on LDCT, matching on LDCT year and age between August 2006, and June 2023. Multivariable conditional logistic regression analysis adjusted for demographic, smoking, and occupational attributes yielded matched adjusted odds ratio (MAOR) with 95% confidence intervals.

Results: Estimated occupational radiation exposure [medium exposure MAOR: 1.58 (1.07, 2.33) and high exposure MAOR: 1.52 (0.99, 2.33)], female (MAOR: 2.67 (2.03, 3.50), African American (MAOR: 2.49 (1.79, 3.45), and obesity [BMI: 30-39.9 MAOR: 1.53 (1.14, 2.06), >40 MAOR: 2.43 (1.55, 3.82)] were significantly associated with thyroid abnormalities.

Conclusion: Further studies of occupationally exposed populations are warranted.

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能源部工作人员低剂量胸部CT扫描中偶发甲状腺异常的危险因素。

目的：评估核武器工人肺癌筛查项目中低剂量CT （LDCT）检测到甲状腺异常的危险因素。方法：我们对有（647例）和无（1941例）LDCT附带甲状腺异常的参与者进行了配对病例对照研究，LDCT的年龄和年龄在2006年8月至2023年6月之间匹配。对人口统计学、吸烟和职业属性进行校正的多变量条件logistic回归分析得出了匹配的校正优势比（MAOR），置信区间为95%。结果：估计职业辐射暴露[中等暴露MAOR: 1.58（1.07, 2.33）和高暴露MAOR: 1.52(0.99, 2.33)]、女性(MAOR: 2.67（2.03, 3.50）、非裔美国人（MAOR: 2.49(1.79, 3.45)）和肥胖[BMI: 30-39.9 MAOR: 1.53 (1.14, 2.06), bbb40 MAOR: 2.43(1.55, 3.82)]与甲状腺异常显著相关。结论：对职业暴露人群的进一步研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of occupational and environmental medicine

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