The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance.

IF 2.5 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2025-09-11 DOI:10.2174/0113894501398484250903074131

Jingjie Yang, Fan Peng, Haodong He, Haoran Liu, Kexing Liu, Zhouya Xu, Yaqi Hu, Guihua Liao, Yan Cai, Chengfu Yuan

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引用次数: 0

Abstract

Introduction: Long intergenic non-coding RNA 01123 (LINC01123) is a lncRNA located on the human chromosome 2q13. It is upregulated in various cancers and has been identified as an oncogene. Its expression is associated with the risk and poor prognosis of multiple cancers.

Methods: A systematic literature search was conducted in PubMed, Web of Science, and Google Scholar databases using "LINC01123" as the search term. The retrieved studies were reviewed to analyze the expression patterns, oncogenic mechanisms, and clinical significance of LINC01123 in cancers.

Results: LINC01123 is activated by transcription factors such as c-Myc, ZEB1, and FOXC1. It promotes cancer progression, metastasis, and drug resistance by acting as a "molecular sponge" for miRNAs, activating signaling pathways, or interacting with proteins. Its upregulation correlates with adverse clinicopathological features and poor prognosis in multiple cancers.

Discussion: The findings suggest that LINC01123 plays a multifaceted role in cancer biology. Its ability to regulate gene expression through various mechanisms highlights its potential as both a prognostic biomarker and a therapeutic target. However, further research is needed to elucidate its mechanisms fully and to explore its clinical applications across different cancer types.

Conclusion: LINC01123 has potential as a novel prognostic biomarker and therapeutic target for cancer. Further research is needed to elucidate its mechanisms and clinical applications fully.

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LINC01123在癌症中的作用、机制和临床意义

长基因间非编码RNA 01123 （LINC01123）是位于人类染色体2q13上的lncRNA。它在各种癌症中被上调，并已被确定为一种致癌基因。它的表达与多种癌症的风险和不良预后相关。方法：以“LINC01123”为检索词，在PubMed、Web of Science和谷歌Scholar数据库中进行系统文献检索。我们对检索到的研究进行综述，分析LINC01123在癌症中的表达模式、致癌机制及其临床意义。结果：LINC01123可被c-Myc、ZEB1和FOXC1等转录因子激活。它通过作为mirna的“分子海绵”、激活信号通路或与蛋白质相互作用，促进癌症的进展、转移和耐药性。它的上调与多种癌症的不良临床病理特征和不良预后相关。讨论：这些发现表明LINC01123在癌症生物学中起着多方面的作用。它通过各种机制调节基因表达的能力突出了它作为预后生物标志物和治疗靶点的潜力。然而，需要进一步的研究来充分阐明其机制并探索其在不同癌症类型中的临床应用。结论：LINC01123有潜力成为一种新的肿瘤预后生物标志物和治疗靶点。进一步的研究需要充分阐明其机制和临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.