Visible-Light-Driven Synthesis of Ester-Substituted Imidazole-Fused Heterocycles via Tandem Radical Cyclization

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-11 DOI:10.1002/ajoc.202500479

Qian Yan, Mai Zhang, Jie Yao, Zi-Han Zhuang, Shi-Hua Chen, Shi-Hai Yang, Zhi-Wei Li, Jiang-Sheng Li

引用次数: 0

Abstract

A novel tandem radical cyclization strategy is reported for the efficient synthesis of ester-functionalized imidazole-fused heterocycles. This method leverages visible-light photocatalysis and modular substrate design to achieve high regioselectivity and atom economy. The protocol demonstrates broad compatibility with diverse N-allylimidazoles and bromoacetates, enabling rapid construction of structurally complex products under mild conditions.

Abstract Image

查看原文本刊更多论文

串联自由基环化在可见光下合成酯取代咪唑-融合杂环

报道了一种新的串联自由基环化策略，用于高效合成酯功能化咪唑-融合杂环。该方法利用可见光光催化和模块化衬底设计来实现高区域选择性和原子经济性。该方案证明了与多种n -烯丙咪唑和溴乙酸盐的广泛相容性，能够在温和条件下快速构建结构复杂的产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.