Advances in the Synthesis and Reactivity of Selenadiazoles

IF 2.7 4区 化学 Q1 CHEMISTRY, ORGANIC
Abdul Qaiyum Ramle, Edward R.T. Tiekink
{"title":"Advances in the Synthesis and Reactivity of Selenadiazoles","authors":"Abdul Qaiyum Ramle,&nbsp;Edward R.T. Tiekink","doi":"10.1002/ajoc.202500577","DOIUrl":null,"url":null,"abstract":"<p>The four isomeric selenadiazoles comprise five-membered SeN<sub>2</sub>C<sub>2</sub> heterocyclic rings and represent a prominent class of organoselenium scaffolds that have received considerable attention in recent years owing to their notable applications in medicinal and materials chemistry. To explore their functionalities, several synthetic methodologies have been developed to diversify these scaffolds with a range of substituents. Cyclization reactions remain the most prevalent approach by employing substituted hydrazines, selonamides, cyano nitriles, and amines under versatile reaction conditions and reagents. This review presents an overview of the strategies reported over the past decade for accessing the four isomeric forms of selenadiazole. The synthetic scope, functionalization and reactivity of the reactions are discussed. Additionally, the non-covalent chalcogen- and halogen-bonding interactions of selected derivatives are reviewed, when present.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500577","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

Abstract

The four isomeric selenadiazoles comprise five-membered SeN2C2 heterocyclic rings and represent a prominent class of organoselenium scaffolds that have received considerable attention in recent years owing to their notable applications in medicinal and materials chemistry. To explore their functionalities, several synthetic methodologies have been developed to diversify these scaffolds with a range of substituents. Cyclization reactions remain the most prevalent approach by employing substituted hydrazines, selonamides, cyano nitriles, and amines under versatile reaction conditions and reagents. This review presents an overview of the strategies reported over the past decade for accessing the four isomeric forms of selenadiazole. The synthetic scope, functionalization and reactivity of the reactions are discussed. Additionally, the non-covalent chalcogen- and halogen-bonding interactions of selected derivatives are reviewed, when present.

Abstract Image

Abstract Image

Abstract Image

Abstract Image

硒二唑类化合物的合成及其反应性研究进展
四种同分异构体硒二唑由五元SeN2C2杂环组成,是一类突出的有机硒支架,近年来因其在药物化学和材料化学中的显著应用而受到广泛关注。为了探索它们的功能,已经开发了几种合成方法,以使这些支架具有一系列取代基。环化反应仍然是最普遍的方法,在多种反应条件和试剂下采用取代肼、塞洛胺、氰基腈和胺。本综述概述了过去十年来报道的获取四种硒二唑异构体的策略。讨论了反应的合成范围、官能化和反应性。此外,非共价键的相互作用,选定的衍生物进行了审查,当存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信