Dr. Li Zhang, Yile Li, Dr. Dayun Huang, Dr. Jinjing Wu
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引用次数: 0
Abstract
Alkenes and alkynes are simple yet important organic feedstocks. The trifluoromethylation of these substrates is able to produce complex organofluorine compounds in a facile way. In this study, we have reviewed decade developments (2014–2024) in the trifluoromethylation of alkenes and alkynes. We discuss various fluorine reagents and their applications. Reagents like CF3SO2Na, CF3SO2Cl, (CF3SO2)2O, N-triflylpyridinium salts, Togni's reagent, PhICF3Cl, Umemoto's reagent and its derivatives, X-RF, trifluoromethyl carbonyl compounds, TFAA, and TMSCF3, will be discussed in detail. The mechanisms and functions of the added reagents have also been discussed. This review covers different reaction types, including radical difunctionalization, cyclization, click reactions, and nucleophilic/electrophilic addition. We hope it will aid future research in this area.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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