Dr. Ayan Mondal, Abhishek Mondal, Satadru Dutta, Prof. Dr. Alakesh Bisai
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引用次数: 0
Abstract
Morphinan alkaloids, including codeine and morphine, are essential natural products with significant pharmacological importance, particularly for pain management. Their complex pentacyclic structure has driven extensive research in synthetic organic chemistry. This review explores the evolution of synthetic approaches to morphinan alkaloids, highlighting advancements in enantioselective strategies, asymmetric catalysis, and biomimetic synthesis. Key milestones, recent innovations in step-economical methods, are discussed. Modern techniques aim to improve yield, reduce steps, and enhance environmental sustainability. These synthetic achievements provide insights into developing opioid analgesics with reduced dependency risks, contributing to safer pain management strategies.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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