A new palladium(II) complex containing ethylenediamine and 2-thioxo-4-thiazolidinone exhibits high activity against resistant Campylobacter jejuni strains

IF 3.2 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-09-11 DOI:10.1016/j.ica.2025.122913

Meiry Leandra de Lacerda , Letícia Roberta Martins Costa , Dayanne Maria da Silva Coimbra , Gabriele de Menezes Pereira , Clara Maria Faria Silva , Pedro Paulo Corbi , Daise Aparecida Rossi , Robson José de Oliveira Júnior , Roberta Torres de Melo , Wendell Guerra

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Abstract

This manuscript describes the synthesis and spectroscopic characterization of two new Pt²⁺ and Pd²⁺ complexes containing ethylenediamine (en) and 2-thioxo-4-thiazolidinone (L1) as ligands. Infrared and NMR data suggest that L1 coordinates to the metal ions in a monodentate manner by the sulfur atom (S⁻). The coordination sphere of the metals is completed by an ethylenediamine molecule coordinated by the two nitrogen atoms. The metal complexes were evaluated against six resistant strains of Campylobacter jejuni. The Pd²⁺ complex (1) was more active than the Pt²⁺ complex (2) and the free ligand (L1), exhibiting high to moderate activity (MBC between 1.56 and 100 μg/mL) against the strains tested. Thereafter, the Pd²⁺ complex was evaluated in a tumoral cell line (B16-F10, murine melanoma) and in two non-tumoral cell lines (NIH/3 T3, mouse fibroblast, and C2C12, mouse myoblast), but no significant activity was observed (IC₅₀ values ≥137.3 μM), suggesting that it does not exhibit considerable toxicity. Thus, the biological data reported here indicate that the Pd²⁺ complex is a promising antibacterial agent which deserves further investigation, since there is a strong need to produce new drugs that are active against multidrug-resistant pathogens.

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一种新的含乙二胺和2-硫氧-4-噻唑烷酮的钯（II）配合物对耐药空肠弯曲杆菌具有较高的活性

本文描述了以乙二胺（en）和2-硫氧-4-噻唑烷酮（L1）为配体的两种新型Pt2+和Pd2+配合物的合成和光谱表征。红外和核磁共振数据表明，L1通过硫原子（S−）与金属离子以单齿方式配位。金属的配位球是由两个氮原子配位的乙二胺分子完成的。研究了金属配合物对6株耐药空肠弯曲杆菌的作用。Pd2+复合物(1)比Pt2+复合物(2)和游离配体（L1）的活性更强，对所测菌株具有高至中等的活性（MBC在1.56 ~ 100 μg/mL之间）。随后，Pd2+复合物在肿瘤细胞系（B16-F10，小鼠黑色素瘤）和两种非肿瘤细胞系（NIH/3 T3，小鼠成纤维细胞和C2C12，小鼠成肌细胞）中进行了评估，但未观察到显著活性（IC50值≥137.3 μM），表明其不具有相当大的毒性。因此，本文报道的生物学数据表明，Pd2+配合物是一种很有前景的抗菌药物，值得进一步研究，因为迫切需要生产对多重耐药病原体有活性的新药。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.