Emerging opportunities in the rewiring of biology through proximity inducing small molecules

Abstract

Biology is reliant on molecular proximity in order to generate the networks and control systems on which it is reliant. The ability to induce or reinforce proximity of macromolecules with exogenous small molecules has emerged as an exciting new potential drug mode of action. This opinion piece looks at some of the background and recent progress, with a particular focus on the alternative opportunities beyond degradation for inducing novel pharmacology.