Detection and characterisation of Xpert CT/NG assay Neisseria gonorrhoeae diagnostic escape mutants, England, June 2025.

IF 7.8 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2025-09-01 DOI:10.2807/1560-7917.ES.2025.30.36.2500673

Melissa Jansen van Rensburg, Rachel Pitt-Kendall, Michelle Hincke, Penelope R Cliff, Jonathan Shaw, Katy Sinka, John Saunders, Helen Fifer, Sarah Alexander

引用次数: 0

Abstract

We report the timely detection of a strain of Neisseria gonorrhoeae which was confirmed as a diagnostic escape mutant on the Cepheid Xpert CT/NG assay in England in June 2025. The reason for assay failure was a likely recombination event with Neisseria meningitidis, which removed both assay target sites. Seven historical putative Xpert CT/NG assay diagnostic escape mutants were also identified following subsequent in silico screening of gonococcal genome collections, but currently there is no evidence of widespread circulation.

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专家CT/NG检测淋病奈瑟菌诊断逃逸突变体的检测和表征，英国，2025年6月。

我们报告在2025年6月在英国的造父变星Xpert CT/NG检测中及时检测到一株淋病奈瑟菌，该菌株被确认为诊断性逃逸突变体。试验失败的原因可能是与脑膜炎奈瑟菌的重组事件，它移除了两个试验靶点。在随后的淋球菌基因组收集的计算机筛选之后，还发现了7个历史上假定的Xpert CT/NG检测诊断逃逸突变体，但目前没有证据表明其广泛传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.