{"title":"Molecular factors driving the development of bovine embryos and embryo-like structures.","authors":"Zongliang Jiang","doi":"10.1590/1984-3143-AR2025-0056","DOIUrl":null,"url":null,"abstract":"<p><p>Understanding the molecular mechanisms regulating the development of bovine pre-implantation embryos and formation of embryo-like structures (blastoids) is essential to uncover the causes of infertility and develop promising novel assisted reproductive technologies (ARTs). This review presents an updated view of functional genome characterization of bovine pre-implantation development. The use of genomic phenotyping and candidate gene perturbation approaches to uncover molecular factors governing bovine early embryonic development are discussed. This review also delves into the latest breakthroughs in the development of bovine blastoids and highlights key molecular signaling for the creation of bovine blastoids.</p>","PeriodicalId":7889,"journal":{"name":"Animal Reproduction","volume":"22 3","pages":"e20250056"},"PeriodicalIF":2.1000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12419253/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Reproduction","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1590/1984-3143-AR2025-0056","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Understanding the molecular mechanisms regulating the development of bovine pre-implantation embryos and formation of embryo-like structures (blastoids) is essential to uncover the causes of infertility and develop promising novel assisted reproductive technologies (ARTs). This review presents an updated view of functional genome characterization of bovine pre-implantation development. The use of genomic phenotyping and candidate gene perturbation approaches to uncover molecular factors governing bovine early embryonic development are discussed. This review also delves into the latest breakthroughs in the development of bovine blastoids and highlights key molecular signaling for the creation of bovine blastoids.
期刊介绍：
Animal Reproduction (AR) publishes original scientific papers and invited literature reviews, in the form of Basic Research, Biotechnology, Applied Research and Review Articles, with the goal of contributing to a better understanding of phenomena related to animal reproduction.
The scope of the journal applies to students, researchers and practitioners in the fields of veterinary, biology and animal science, also being of interest to practitioners of human medicine. Animal Reproduction Journal is the official organ of the Brazilian College of Animal Reproduction in Brazil.
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