Ultrasound mediated chemical synthesis of 2-aryl substituted benzothiazoles derivatives using merrifield resin supported ionic liquid as organocatalyst

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-08-21 DOI:10.1007/s11164-025-05701-6

Ayushi Aggarwal, Harish Kumar Chopra

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Abstract

Herein, the study synthesized a series of reusable and efficient Benzoxazolium-based Merrifield resin Supported Ionic Liquids (MRBO-SILs) as organocatalyst by refluxing a mixture of merrifield resin (chemically inert and non-toxic) and benzoxazole. The synthesized catalyst MRBO-SILs were used for the greener synthesis of wide range of medically active 2-substituted benzothiazoles from substituted aldehydes and 2-aminothiophenol in 60% EtOH under ultrasonication. The resulting protocol is remarkably effective for synthesis because it adheres to green chemistry principles and has many more advantages than those mentioned in earlier studies. These advantages include a smooth reaction, the use of EtOH as a solvent, short reaction time (2–5 min), excellent yield (> 95%), ambient temperature (25 ℃), an easy workup procedure, catalyst recycling, and high atom economy. Furthermore, the catalyst's catalytic activity would not diminish even after eight cycles of reuse.

Graphical abstract

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以梅里菲尔德树脂负载离子液体为有机催化剂，超声介导化学合成2-芳基取代苯并噻唑衍生物

本研究以化学惰性且无毒的梅里菲尔德树脂与苯并恶唑的混合物为溶剂回流，合成了一系列可重复使用且高效的苯并恶唑基梅里菲尔德树脂负载离子液体（MRBO-SILs）作为有机催化剂。利用合成的催化剂MRBO-SILs，以取代醛和2-氨基噻吩为原料，在60%的乙醚条件下超声合成了多种具有广泛医学活性的2-取代苯并噻唑。由此产生的方案对于合成是非常有效的，因为它遵循绿色化学原则，并且比早期研究中提到的有更多的优点。这些优点包括反应平稳，使用乙烯醇作为溶剂，反应时间短（2-5分钟），收率高（95%），环境温度（25℃），简单的处理程序，催化剂循环利用和高原子经济性。此外，即使经过8次循环使用，催化剂的催化活性也不会降低。图形抽象

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.