7-Methylguanine nucleotides and their structural analogues; protolytic equilibria, complexing with magnesium (II) ion and kinetics for alkaline opening of the imidazole ring.

E Darzynkiewicz, I Labadi, D Haber, K Burger, H Lönnberg
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引用次数: 16

Abstract

First-order rate constants for the alkaline opening of the imidazole ring of several 7-methylguanine nucleotides and their structural analogues were determined. The results obtained suggested that intramolecular interaction between the negatively charged 5'-phosphate group and the positively charged imidazole ring markedly retard the attack of hydroxide ion on the C8 atom of the 7-methylguanine ring. In contrast, hardly any influence on the acidities of the interacting base and phosphate moieties was detectable. No effect on the complexing of the phosphate group with magnesium(II) ion could be detected.

7-甲基鸟嘌呤核苷酸及其结构类似物;原解平衡、与镁离子络合及咪唑环碱性开环动力学。
测定了几种7-甲基鸟嘌呤核苷酸及其结构类似物的咪唑环碱性开环的一级速率常数。结果表明,带负电的5'-磷酸基团与带正电的咪唑环之间的分子内相互作用明显延缓了氢氧根离子对7-甲基鸟嘌呤环C8原子的攻击。相比之下,对相互作用的碱和磷酸盐部分的酸度几乎没有任何影响。对磷酸基与镁离子的络合作用没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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