Commentary on “The Association of Circulating Bone Morphogenetic Protein 9 and Arterial Stiffness in Hypertensive Patients”

IF 2.5 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Clinical Hypertension Pub Date : 2025-09-11 DOI:10.1111/jch.70133

Naghmeh Ziaie, Mohammad Barary, Mostafa Javanian, Soheil Bakhshinasab, Soheil Ebrahimpour

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引用次数: 0

Abstract

Dear Editor,

In summary, BMP-9 shows biologic plausibility and modest discriminative power for arterial stiffness, but residual confounding, single-time-point measurement, and limited external validity temper enthusiasm for immediate clinical adoption. Future longitudinal, population-based studies incorporating richer lifestyle, pharmacologic, and inflammatory data, and reporting decision-analytic metrics, are essential to define the incremental value of BMP-9-guided risk stratification in hypertension care.

Majid Khalilizad: investigation, writing - original draft preparation. Mehdi Tavassoli: investigation, writing - original draft preparation. Mohammad Barary: investigation, writing - original draft preparation, writing - review and editing. Mostafa Javanian: investigation, writing - original draft preparation. Soheil Ebrahimpour: investigation, supervision, writing - original draft preparation. All authors contributed significantly to the work and approved the final version of the manuscript. Their contributions align with the latest guidelines of the International Committee of Medical Journal Editors.

The authors have nothing to report.

The authors declare no conflicts of interest.

查看原文本刊更多论文

“高血压患者循环骨形态发生蛋白9与动脉僵硬的关系”评论。

总而言之，BMP-9在动脉硬度方面显示出生物学上的合理性和适度的鉴别能力，但残留的混淆、单时间点测量和有限的外部效度降低了立即临床采用的热情。未来的纵向、基于人群的研究纳入更丰富的生活方式、药理学和炎症数据，并报告决策分析指标，对于确定bmp -9引导的高血压护理风险分层的增量价值至关重要。马吉德·哈利利扎德：调查、写作——原稿准备。马赫迪·塔瓦索利：调查、写作——原稿准备。Mohammad Barary：调查，写作-原稿准备，写作-审查和编辑。穆斯塔法·爪哇语：调查、写作——原稿准备。Soheil Ebrahimpour：调查，监督，写作-原稿准备。所有作者都对这项工作做出了重大贡献，并批准了手稿的最终版本。他们的贡献符合国际医学期刊编辑委员会的最新指导方针。作者没有什么可报告的。作者没有什么可报告的。作者声明无利益冲突。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Hypertension PERIPHERAL VASCULAR DISEASE-

CiteScore

5.80

自引率

7.10%

发文量

191

审稿时长

4-8 weeks

期刊介绍： The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.