Perturbing neural stem cell fate in glioblastoma heterogeneity and beyond.

IF 5.1 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Reports Pub Date : 2025-09-09 DOI:10.1016/j.stemcr.2025.102633

Ethan W Hollingsworth, Jaime Imitola

引用次数: 0

Abstract

Intratumoral heterogeneity in glioblastoma is thought to underlie its remarkable ability to recur and resist therapies. Its origins, however, remain unknown. In this issue, Liu et al. model the contributions of cell-of-origin and genetic drivers to intratumoral heterogeneity in glioblastoma, using a perturbation paradigm with broad neurodevelopmental applications.

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神经干细胞命运在胶质母细胞瘤异质性及其他方面的干扰。

胶质母细胞瘤的肿瘤内异质性被认为是其显著复发和抵抗治疗能力的基础。然而，它的起源仍然未知。在这一期中，Liu等人使用具有广泛神经发育应用的扰动范式，模拟了胶质母细胞瘤中细胞起源和遗传驱动因素对肿瘤内异质性的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

10.50

自引率

1.70%

发文量

200

审稿时长

28 weeks

期刊介绍： Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.