Safety Assessment of Levulinic Acid and Sodium Levulinate as Used in Cosmetics.

IF 1 4区医学 Q4 PHARMACOLOGY & PHARMACY

International Journal of Toxicology Pub Date : 2025-10-01 Epub Date: 2025-09-11 DOI:10.1177/10915818251359228

Preethi S Raj, Wilma F Bergfeld, Donald V Belsito, David E Cohen, Curtis D Klaassen, Daniel C Liebler, James G Marks, Lisa A Peterson, Ronald C Shank, Thomas J Slaga, Paul W Snyder, Monice M Fiume, Bart Heldreth

引用次数: 0

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Levulinic Acid and Sodium Levulinate as used in cosmetic formulations. These ingredients are both reported to function in cosmetics as skin conditioning agents, while Levulinic Acid is also reported to function as a fragrance ingredient. The Panel reviewed relevant data relating to the safety of these ingredients in cosmetic formulations, and concluded that these ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.

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化妆品用乙酰丙酸和乙酰丙酸钠的安全性评价。

化妆品成分安全专家小组（专家小组）评估了用于化妆品配方的乙酰丙酸和乙酰丙酸钠的安全性。据报道，这两种成分都是化妆品中的皮肤调理剂，而乙酰丙酸也被报道为香味成分。评估小组审查了化妆品配方中这些成分安全性的相关数据，得出结论认为，在本安全评估中所述的现行使用方法和浓度下，这些成分在配制成无刺激性的化妆品中是安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Toxicology 医学-毒理学

CiteScore

3.40

自引率

4.50%

发文量

审稿时长

4.5 months

期刊介绍： The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Review Expert Panel.