Network pharmacology approach and experimental verification of Manzufei decoction in the treatment of chronic obstructive pulmonary disease.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-11 DOI:10.1080/10286020.2025.2558646

Xin Liu, Chun-Ye Hu, Zheng-Huan Li, Hong-Mei Yang, Cheng-Xin Zhang, Hong Li, Guo-Ming Tang, Yang Chen

引用次数: 0

Abstract

Manzufei decoction (MZFD) effectively treats COPD, but its mechanisms are unclear. Combining network pharmacology and experimental validation, we identified 168 bioactive components in MZFD and 265 potential targets. Network analysis pinpointed 4 core compounds. Comparing 1167 COPD-related targets revealed 114 overlapping therapeutic targets. Enrichment analysis implicated key pathways, notably AKT signaling. Molecular docking confirmed strong binding of quercetin to AKT and MUC5AC. Animal studies demonstrated that MZFD inhibits AKT signaling pathway activation, reduces MUC5AC protein expression in lung tissue and lung inflammation, thereby alleviating lung injury in AECOPD model rats.

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曼祖肺汤治疗慢性阻塞性肺疾病的网络药理学方法及实验验证。

满足肺汤治疗慢性阻塞性肺病疗效显著，但其作用机制尚不清楚。结合网络药理学和实验验证，我们鉴定出了MZFD中168个生物活性成分和265个潜在靶点。网络分析确定了4个核心化合物。比较1167个copd相关靶点，发现114个重叠的治疗靶点。富集分析涉及关键通路，特别是AKT信号。分子对接证实槲皮素与AKT和MUC5AC有较强的结合。动物实验表明，MZFD抑制AKT信号通路激活，降低肺组织MUC5AC蛋白表达和肺部炎症，从而减轻AECOPD模型大鼠的肺损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.