Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-08-26 eCollection Date: 2025-09-01 DOI:10.1093/ofid/ofaf515

Shaun Pienkos, Zoe Swank, Rebecca E Hamlin, Mallika Rao, Phillip Grant, Hector Bonilla, Karen Jacobson, Prasanna Jagannathan, Upinder Singh, David R Walt, Aruna Subramanian, Catherine Blish

引用次数: 0

Abstract

Plasma samples obtained approximately 3 (n = 100) and 12 months (n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein expression levels on immune cells between those with and without plasma antigen detected.

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单细胞和血浆蛋白质组学不能区分100例患者恢复期是否存在SARS-CoV-2抗原血症。

在急性SARS-CoV-2感染后约3个月（n = 100）和12个月（n = 78）采集血浆样本，检测S1、spike和n抗原。血浆抗原检测组和未检测组在免疫细胞上的血浆蛋白和单细胞蛋白表达水平无显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.