{"title":"Diagnostic accuracy of combination of CA125 for endometriosis: A network meta-analysis.","authors":"Lan Wu, Zeyu Yang, Han Chen, Yunhe Piao","doi":"10.1002/ijgo.70509","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Currently, CA125 combined with other biomarkers significantly outperforms CA125 alone in diagnosing endometriosis (EM), but the efficiency of combined diagnosis remains unclear. This network meta-analysis compared the accuracy of CA125 combined with different biomarkers in diagnosing EM.</p><p><strong>Objectives: </strong>The aim of this study was to conduct a network meta-analysis (NMA) to evaluate the diagnostic accuracy of CA125 combined with different biomarkers for EM.</p><p><strong>Methods: </strong>Data were sourced from PubMed, Embase, Cochrane Library, and Web of Science databases. This meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses guidelines. Studies that compared the diagnostic accuracy between CA125 plus other biomarkers and CA125 alone (control) in patients with suspected EM were included. The agreement between CA125 alone and in combination with other biomarkers was assessed. NMA was performed, and the surface under the cumulative ranking curve (SUCRA) values were obtained to calculate the probability of which combination would be the most effective diagnostic method. The CINeMA tool was used to assess the quality of the included studies.</p><p><strong>Results: </strong>Direct comparison and inconsistency test and NMA were performed, and SUCRA values were obtained. A total of 10 articles were eligible for inclusion. CA125+CA19+IL-6 showed the highest SUCRA value in terms of sensitivity, positive predictive value and precision, followed by CA125+NLR. The quality of the included evidence was classified as moderate.</p><p><strong>Conclusion: </strong>This meta-analysis shows that CA125+CA199+IL-6 might be more efficient for diagnosing EM compared with other diagnostic methods.</p>","PeriodicalId":14164,"journal":{"name":"International Journal of Gynecology & Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Gynecology & Obstetrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ijgo.70509","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Currently, CA125 combined with other biomarkers significantly outperforms CA125 alone in diagnosing endometriosis (EM), but the efficiency of combined diagnosis remains unclear. This network meta-analysis compared the accuracy of CA125 combined with different biomarkers in diagnosing EM.
Objectives: The aim of this study was to conduct a network meta-analysis (NMA) to evaluate the diagnostic accuracy of CA125 combined with different biomarkers for EM.
Methods: Data were sourced from PubMed, Embase, Cochrane Library, and Web of Science databases. This meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses guidelines. Studies that compared the diagnostic accuracy between CA125 plus other biomarkers and CA125 alone (control) in patients with suspected EM were included. The agreement between CA125 alone and in combination with other biomarkers was assessed. NMA was performed, and the surface under the cumulative ranking curve (SUCRA) values were obtained to calculate the probability of which combination would be the most effective diagnostic method. The CINeMA tool was used to assess the quality of the included studies.
Results: Direct comparison and inconsistency test and NMA were performed, and SUCRA values were obtained. A total of 10 articles were eligible for inclusion. CA125+CA19+IL-6 showed the highest SUCRA value in terms of sensitivity, positive predictive value and precision, followed by CA125+NLR. The quality of the included evidence was classified as moderate.
Conclusion: This meta-analysis shows that CA125+CA199+IL-6 might be more efficient for diagnosing EM compared with other diagnostic methods.
背景：目前，CA125联合其他生物标志物在诊断子宫内膜异位症（EM）方面明显优于单独使用CA125，但联合诊断的效率尚不清楚。目的：本研究旨在通过网络meta分析（network meta analysis， NMA）评价CA125联合不同生物标志物对em的诊断准确性。方法：数据来源于PubMed、Embase、Cochrane Library和Web of Science数据库。本荟萃分析按照系统评价和荟萃分析指南的首选报告项目进行。在疑似EM患者中，比较CA125加其他生物标志物与单独CA125（对照组）的诊断准确性的研究被纳入。评估CA125单独和与其他生物标志物联合的一致性。进行NMA分析，得到累积排序曲线（SUCRA）值下的曲面，计算出哪种组合是最有效的诊断方法的概率。使用CINeMA工具评估纳入研究的质量。结果：进行直接比较、不一致检验和NMA，得到SUCRA值。共有10篇文章符合纳入条件。CA125+CA19+IL-6的SUCRA值在敏感性、阳性预测值和准确性方面最高，其次是CA125+NLR。纳入证据的质量被归类为中等。结论：与其他诊断方法相比，CA125+CA199+IL-6可能更有效地诊断EM。
期刊介绍：
The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.
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