Association between serum copper and childhood asthma: A systematic review and meta-analysis.

IF 2.1 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI:10.15586/aei.v53i5.1394

Beilei Wang, Xingyue Su, Xiang Ma

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引用次数: 0

Abstract

Background: Asthma is a chronic respiratory disease with complex pathogenesis. Some studies suggest that certain trace metals may be associated with asthma. However, the relationship between serum copper (Cu) and childhood asthma remains unclear. This meta-analysis evaluates the association between Cu and childhood asthma.

Methods: Studies of multiple databases were searched from inception to 2024. We recorded the standardized mean difference (SMD), 95% confidence intervals (CIs), and other data. The analysis was performed using Stata 18.0 software. Two independent reviewers appraised methodological quality using the Newcastle-Ottawa Scale. Sensitivity analysis was used to test robustness. To evaluate publication bias, we used Begg's funnel plots and Egger's regression test.

Results: A total of 11 studies with a combined 1006 participants were included. There was no significant difference in the level of serum Cu between children with asthma cases and controls (SMD = -0.032, 95% CI: -0.291-0.228, P = 0.811). There was significant heterogeneity among the studies (I² = 73.5%, P < 0.0001). Subgroup analysis demonstrated that heterogeneity was not caused by the continent of origin, publication year, sample size, detection methods, and the mean age of participants. No publication bias was found.

Conclusion: There is no statistically significant association between serum Cu levels and childhood asthma. Further research, particularly large-scale prospective cohort studies, is needed to clarify this relationship.

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血清铜与儿童哮喘的关系：一项系统回顾和荟萃分析。

背景：哮喘是一种发病机制复杂的慢性呼吸道疾病。一些研究表明，某些微量金属可能与哮喘有关。然而，血清铜（Cu）与儿童哮喘之间的关系尚不清楚。这项荟萃分析评估了铜与儿童哮喘之间的关系。方法：检索自成立至2024年多个数据库的研究。我们记录了标准化平均差（SMD）、95%置信区间（ci）和其他数据。采用Stata 18.0软件进行分析。两名独立评审员使用纽卡斯尔-渥太华量表评估方法质量。采用敏感性分析检验稳健性。为了评价发表偏倚，我们使用Begg的漏斗图和Egger的回归检验。结果：共纳入11项研究，共1006名受试者。哮喘患儿血清Cu水平与对照组比较，差异无统计学意义（SMD = -0.032, 95% CI: -0.291-0.228, P = 0.811）。研究间存在显著异质性（I2 = 73.5%, P < 0.0001）。亚组分析表明，异质性不是由原产大陆、发表年份、样本量、检测方法和参与者的平均年龄引起的。未发现发表偏倚。结论：血清铜水平与儿童哮喘无显著相关性。需要进一步的研究，特别是大规模的前瞻性队列研究来澄清这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.