Glucose restriction: double edged sword in cancer treatment.

IF 17.5 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-09-05 DOI:10.1016/j.trecan.2025.08.012

Shenglong Xia, Dingjiacheng Jia

引用次数: 0

Abstract

Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural killer (NK) cell-deficient pre-metastatic niche (PMN). This finding provides a new perspective on understanding the dual role of glucose metabolism regulation in cancer treatment.

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限制血糖：治疗癌症的双刃剑。

葡萄糖限制通常会限制肿瘤的生长。最近，Wu等人报道葡萄糖限制抑制原发肿瘤，但通过形成巨噬细胞主导的自然杀伤（NK）细胞缺陷转移前生态位（PMN）促进肺转移。这一发现为理解糖代谢调节在癌症治疗中的双重作用提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.