Combination of photodynamic therapy and estrogen cream for menopause women with cervical low-grade squamous intraepithelial lesion with human papillomavirus infection

IF 2.6 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-09-03 DOI:10.1016/j.pdpdt.2025.104791

Wendi Yang , Guoqing Jiang , Yunduo Liu , Lijing Zhang , Yajun Li

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引用次数: 0

Abstract

Background

In menopausal women, decreased estrogen levels lead to genital tract mucosal atrophy and reduced mucosal immune function. Low-grade squamous intraepithelial lesions (LSIL) associated with persistent or newly acquired high-risk HPV infection may progress silently to high-grade squamous intraepithelial lesions (HSIL) and eventually cervical cancer.

Objective

: This study aimed to evaluate the efficacy and safety of photodynamic therapy combined with estrogen in the treatment of menopausal women with LSIL and high-risk HPV infection.

Methods

A retrospective controlled study was conducted to compare LSIL regression and HPV clearance among three treatment groups: photodynamic therapy plus estrogen, interferon gel plus estrogen, and estrogen alone. Therapeutic outcomes were assessed using ThinPrep cytology (TCT), HPV testing, and colposcopic pathology at 3, 6, and 12 months post-treatment.

Results

The rates of LSIL regression and HPV clearance in the photodynamic therapy plus estrogen group were significantly higher than those in both the interferon gel plus estrogen group and the estrogen-alone group at 3, 6, and 12 months (p < 0.05). Furthermore, the interferon gel plus estrogen group showed improved outcomes compared to estrogen alone, with statistically significant differences (p < 0.05).

Conclusion

Photodynamic therapy combined with estrogen cream is an effective and safe treatment approach for menopausal women with LSIL and high-risk HPV infection.

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光动力疗法联合雌激素乳膏治疗绝经期妇女宫颈低级别鳞状上皮内病变合并人乳头瘤病毒感染。

背景：绝经期妇女雌激素水平降低导致生殖道黏膜萎缩和黏膜免疫功能降低。与持续或新获得的高危HPV感染相关的低级别鳞状上皮内病变（LSIL）可能悄无声息地发展为高级别鳞状上皮内病变（HSIL）并最终发展为宫颈癌。目的：本研究旨在评价光动力疗法联合雌激素治疗绝经期LSIL合并高危HPV感染的疗效和安全性。方法：采用回顾性对照研究，比较光动力治疗加雌激素组、干扰素凝胶加雌激素组和单独雌激素组的LSIL消退和HPV清除率。在治疗后3、6和12个月，使用ThinPrep细胞学（TCT）、HPV检测和阴道镜病理评估治疗结果。结果：光动力治疗联合雌激素组在3、6、12个月时LSIL消退率和HPV清除率均显著高于干扰素凝胶联合雌激素组和单独雌激素组（p < 0.05）。干扰素凝胶联合雌激素组较单独雌激素组疗效改善，差异有统计学意义（p < 0.05）。结论：光动力疗法联合雌激素乳膏是治疗绝经期低sil合并高危HPV感染的有效、安全的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.