Vagus block blocks cachexia

IF 20 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-09-05 DOI:10.1038/s41593-025-02058-2

Leonie Welberg

引用次数: 0

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迷走神经阻滞阻滞恶病质

癌症引起的恶病质是一种危及生命的疾病，目前尚无有效的治疗方法。其机制复杂，涉及肝功能改变引起的代谢改变。Garrett、Darzi等人在Cell杂志上发表文章称，在肺癌或胰腺癌小鼠模型中，迷走神经活动模式发生改变，迷走神经背侧运动核（VDMN）活动增加。在此之前，VDMN和肝脏中趋化因子CCL2水平升高，而调节肝细胞基因表达从而调节肝脏代谢的肝细胞核因子4-α (HNF4α)表达降低。阻断CCL2功能可减少迷走神经改变和恶病质症状。切断右颈迷走神经可减少肌肉萎缩、体重减轻、厌食和抑郁样行为，增加肝脏HNF4α水平，改善肝功能，延长寿命，但没有减少肿瘤大小。每日应用经皮低频交流电（LFAC）阻断迷走神经传导具有相似的效果，可恢复迷走神经张力；LFAC阻滞联合化疗可增加生存获益。这些发现提供了经皮LFAC阻断右侧迷走神经可以减轻癌症恶病质和提高生存率的概念验证证据。原始参考文献：Cell https://doi.org/10.1016/j.cell.2025.07.016 （2025）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.