{"title":"[Age-associated changes of the immune system: immunosenescence and effects on vaccinations].","authors":"Birgit Weinberger, Peter Dovjak","doi":"10.1007/s00391-025-02496-4","DOIUrl":null,"url":null,"abstract":"<p><p>Complex changes of the innate and adaptive immune system occur in old age and contribute to the increased frequency and severity of infections in older adults. At the same time, chronic, subclinical inflammation occurs, which promotes age-related diseases. Age-associated changes in the immune system also influence the formation, growth and metastasis of malignant tumors. Furthermore, there are indications that the aging of the immune system contributes to the development of autoimmunity. Vaccinations are an important preventive measure for maintaining health and improving the quality of life, not only but especially in old age. The development of optimized and new vaccines for the older population has made great progress in recent years and decades; however, vaccination rates among older adults are well below target for all vaccinations.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"517-527"},"PeriodicalIF":1.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454514/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift Fur Gerontologie Und Geriatrie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00391-025-02496-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Complex changes of the innate and adaptive immune system occur in old age and contribute to the increased frequency and severity of infections in older adults. At the same time, chronic, subclinical inflammation occurs, which promotes age-related diseases. Age-associated changes in the immune system also influence the formation, growth and metastasis of malignant tumors. Furthermore, there are indications that the aging of the immune system contributes to the development of autoimmunity. Vaccinations are an important preventive measure for maintaining health and improving the quality of life, not only but especially in old age. The development of optimized and new vaccines for the older population has made great progress in recent years and decades; however, vaccination rates among older adults are well below target for all vaccinations.
期刊介绍：
The fact that more and more people are becoming older and are having a significant influence on our society is due to intensive geriatric research and geriatric medicine in the past and present. The Zeitschrift für Gerontologie und Geriatrie has contributed to this area for many years by informing a broad spectrum of interested readers about various developments in gerontology research. Special issues focus on all questions concerning gerontology, biology and basic research of aging, geriatric research, psychology and sociology as well as practical aspects of geriatric care.
Target group: Geriatricians, social gerontologists, geriatric psychologists, geriatric psychiatrists, nurses/caregivers, nurse researchers, biogerontologists in geriatric wards/clinics, gerontological institutes, and institutions of teaching and further or continuing education.
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