Multitargeting neuroimmune pathways: novel candidates for chronic pain relief.

IF 19.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2025-10-01 Epub Date: 2025-09-03 DOI:10.1016/j.tips.2025.08.005

María Florencia Coronel, Marcelo José Villar, Pablo Rodolfo Brumovsky

引用次数: 0

Abstract

Chronic pain remains inadequately managed, partly because of insufficient consideration of neuroimmune interactions in therapeutic design and a continued reliance on single-target strategies ill-suited to its complexity. Multitarget-directed ligands that modulate the non-neuronal microenvironment of neuronal pain pathways show promise, supported by encouraging preclinical data and initial clinical findings.

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多靶点神经免疫通路：缓解慢性疼痛的新候选药物。

慢性疼痛仍然没有得到充分的控制，部分原因是治疗设计中没有充分考虑神经免疫相互作用，并且继续依赖于不适合其复杂性的单靶点策略。多靶点定向配体调节神经元疼痛通路的非神经元微环境显示出希望，这得到了令人鼓舞的临床前数据和初步临床发现的支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.