Zihan Chen, Ka Fai Leong, Yuhan Xie, Alessandra Gianoncelli, Giovanni Ribaudo, Paolo Coghi
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引用次数: 0
Abstract
Arthritis has become a global public health issue due to its diverse risk factors and high prevalence. Therefore, there is a demand for more effective drugs to improve these situations. Triterpenoids have attracted the interest of researchers because of their broad spectrum of biological activities and pharmacological effects. The aim of this review is to provide an updated overview of the potential of triterpenoids and of their derivatives as therapeutic agents against Rheumatoid Arthritis (RA) and Osteoarthritis (OA), based on their anti-inflammatory and immunomodulatory properties. This review discusses the chemical and pharmacological properties of triterpenoids and their derivatives, focusing on the different mechanisms by which this class of compounds achieves therapeutic benefits in arthritis. The conclusions indicate that triterpenoids and their derivatives have a favorable potential therapeutic effect on arthritis.
期刊介绍：
The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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