Evaluation of a Novel Short-Contact Therapy With 4% Glycyrrhetinic Acid Complex Gel for Scalp Seborrheic Dermatitis: A Pre- and Postintervention Study

IF 3.4 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-09-05 DOI:10.1155/dth/4298078

Chii-Shyan Wang, Hsiao-Chi Wang, Hsuan-Hsiang Chen

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引用次数: 0

Abstract

Background: Scalp seborrheic dermatitis (SSD) is a chronic inflammatory dermatosis characterized by sebum imbalance and proliferation of Malassezia species. While various antifungal shampoos are commonly used to manage SSD, there remains a substantial demand for alternative treatments that provide a more rapid onset of action. Glycyrrhetinic acid is recognized for its antioxidative, anti-inflammatory, antimicrobial, and antiallergic properties. This study aimed to evaluate the efficacy of a novel scalp gel containing 4% glycyrrhetinic acid complex as a short-contact therapy for SSD.

Methods: A total of 40 patients with SSD were enrolled in this study and treated with the 4% glycyrrhetinic acid complex gel using a short-contact therapy approach. Clinical efficacy was assessed by the Adherent Scalp Flaking Score (ASFS) and Dermatology Life Quality Index (DLQI) at baseline, Week 1, and Week 2, all evaluated by the same dermatologist. Treatment satisfaction was measured at Week 2 using the Treatment Satisfaction Questionnaire (TSQ).

Results: Significant improvements in ASFS and DLQI were observed at both Week 1 and Week 2 compared to baseline. Patient satisfaction, as measured by the TSQ, yielded a mean score of 4.2 ± 0.8 on a 5-point scale.

Conclusions: This study demonstrates the clinical efficacy of the novel 4% glycyrrhetinic acid complex scalp gel as a short-contact therapy for SSD. The rapid onset of action and significant improvement in symptoms suggest that this gel could serve as an effective alternative for managing SSD in the acute phase.

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4%甘草次酸复合凝胶治疗头皮脂溢性皮炎的新型短接触治疗评价：干预前和干预后研究

背景：头皮脂溢性皮炎（SSD）是一种以皮脂失衡和马拉色菌增生为特征的慢性炎症性皮肤病。虽然各种抗真菌洗发水通常用于治疗SSD，但仍然存在对提供更快起作用的替代治疗的大量需求。甘草次酸被认为具有抗氧化、抗炎、抗菌和抗过敏的特性。本研究旨在评估一种含有4%甘草次酸复合物的新型头皮凝胶作为短接触治疗SSD的疗效。方法：本研究共纳入40例SSD患者，采用4%甘草次酸络合凝胶短接触治疗方法治疗。临床疗效通过基线、第1周和第2周的粘附性头皮脱落评分（ASFS）和皮肤科生活质量指数（DLQI）进行评估，所有评估均由同一皮肤科医生进行。在第2周使用治疗满意度问卷（TSQ）测量治疗满意度。结果：与基线相比，第1周和第2周ASFS和DLQI均有显著改善。通过TSQ测量，患者满意度在5分制中平均得分为4.2±0.8。结论：本研究证实了新型4%甘草次酸复合头皮凝胶作为一种短接触治疗SSD的临床疗效。快速起效和显著改善症状表明，该凝胶可作为治疗急性期SSD的有效替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.