From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-09-04 DOI:10.1016/j.stem.2025.08.001

Jia Zhao, Shenghui Liang, Timothy J. Kieffer

引用次数: 0

Abstract

While current stem cell differentiation protocols generate β cell-enriched islets that reverse hyperglycemia post-implantation, they can cause hypoglycemia. Meng et al.¹ reconstruct endocrine subtype-complete islets, which restore counterregulatory responses and protect against hypoglycemia in diabetic mice, highlighting the importance of endocrine diversity in designing physiologically regulated cell therapies for diabetes.

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从β独奏家到内分泌交响乐：亚型完全胰岛指挥葡萄糖和谐

虽然目前的干细胞分化方案产生富含β细胞的胰岛，可以逆转植入后的高血糖，但它们可能导致低血糖。孟等人重建了内分泌亚型完全胰岛，该胰岛可以恢复糖尿病小鼠的反调节反应并防止低血糖，强调了内分泌多样性在设计生理调节的糖尿病细胞疗法中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.