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Blocking SKI-1 to rescue the blood–brain barrier and improve stroke recovery

IF 10.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Nature cardiovascular research Pub Date : 2025-08-26 DOI:10.1038/s44161-025-00683-5
Ken Arai, Masafumi Ihara
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Abstract

The blood–brain barrier is an important therapeutic target in the development of drugs to treat stroke. A recent study finds that inhibiting SKI-1 protects blood–brain barrier integrity and improves neurological recovery in mouse and rabbit models of stroke.

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阻断SKI-1挽救血脑屏障，改善中风恢复。
血脑屏障是脑卒中治疗药物开发中的一个重要靶点。最近的一项研究发现，抑制SKI-1可以保护血脑屏障的完整性，并改善小鼠和家兔中风模型的神经恢复。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
Nature cardiovascular research
Nature cardiovascular research
CiteScore
5.70
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0.00%
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