Xanthogranulomatous Epithelial Tumor in a Pediatric Patient. A Potential Diagnostic Pitfall With Non-Langerhans Cell Histiocytic Neoplasms, Particularly Juvenile Xanthogranuloma.

IF 1 4区医学 Q4 DERMATOLOGY

American Journal of Dermatopathology Pub Date : 2025-09-03 DOI:10.1097/DAD.0000000000003120

Danielle V de Stefano, Jennifer Picarsic, Somak Roy, Eduardo Zambrano Tola

引用次数: 0

Abstract

Abstract: Xanthogranulomatous epithelial tumor is a recently described neoplasm harboring recurrent HMGA2::NCOR2 fusions, which, owing to its extensive xanthogranulomatous appearance with abundant foamy histiocytes and frequent Touton-type giant cells, may be confused with other inflammatory and neoplastic entities. We present a case arising in the right arm subcutaneous tissues of a 10-year-old boy, which was initially interpreted as a non-Langerhans cell histiocytic neoplasm compatible with Juvenile xanthogranuloma.

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儿科患者黄色肉芽肿性上皮肿瘤。非朗格汉斯细胞组织细胞肿瘤的一个潜在诊断缺陷，尤其是幼年黄色肉芽肿。

摘要：黄色肉芽肿上皮肿瘤是一种新近发现的含有复发性HMGA2::NCOR2融合的肿瘤，由于其广泛的黄色肉芽肿外观，丰富的泡沫组织细胞和频繁的touton型巨细胞，可能与其他炎症和肿瘤实体相混淆。我们报告了一个10岁男孩右臂皮下组织的病例，最初被解释为非朗格汉斯细胞组织细胞肿瘤与幼年黄色肉芽肿相容。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Dermatopathology 医学-皮肤病学

CiteScore

1.80

自引率

9.10%

发文量

453

审稿时长

3 months

期刊介绍： The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians