Is dental clearance necessary before antiresorptive treatment in pediatric patients?

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-05 DOI:10.1016/j.oooo.2025.07.015

Timothy W Neal, Sayyed Mohseni, Victoria Ratcliffe, Thomas Schlieve

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引用次数: 0

Abstract

Introduction: This study aimed to determine if there was a difference in the frequency of medication-related osteonecrosis of the jaws (MRONJ) between pediatric patients who obtained dental clearance and those who didn't obtain dental clearance before the start of antiresorptive therapy. The secondary aim was to assess the effect of dental clearance on future dental follow-up after the start of antiresorptive treatment.

Materials and methods: The study population was composed of patients less than 18 years of age who received antiresorptive treatment from 2010 to 2024 at Children's Medical Center Dallas.

Results: There were 88 subjects in the clearance group and 48 in the no-clearance group. No cases of MRONJ were observed in either group. The clearance group mean dental visits per year after the start of antiresorptive therapy was 1.21 (SD 0.96), and 0.55 (0.65) for the no-clearance group. There was a significant difference between the two groups (P = .0002).

Discussion: No cases of MRONJ were observed in the present study. In pediatric patients who receive dental clearance prior to the start of antiresorptive medications, there is an association with continued routine dental follow-up.

查看原文本刊更多论文

儿科患者抗吸收治疗前是否有必要清除牙齿？

前言：本研究旨在确定在抗吸收治疗开始前获得牙齿清除和未获得牙齿清除的儿童患者之间药物相关性颌骨骨坏死（MRONJ）的频率是否存在差异。第二个目的是评估在抗吸收治疗开始后，牙间隙对未来牙科随访的影响。材料和方法：研究人群由2010年至2024年在达拉斯儿童医疗中心接受抗吸收治疗的18岁以下患者组成。结果：清除率组88例，无清除率组48例。两组均未见MRONJ病例。清除组在抗吸收治疗开始后平均每年牙科就诊次数为1.21次（SD 0.96），无清除组为0.55次（0.65）。两组间差异有统计学意义（P = 0.0002）。讨论：本研究未发现MRONJ病例。在抗吸收药物开始前接受牙齿清除的儿科患者，与继续常规牙科随访有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.