Synthetic biology-inspired development of live attenuated influenza vaccines.

IF 6.5 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-08-27 DOI:10.1038/s41541-025-01255-1

Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si

引用次数: 0

Abstract

Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns. Recent advances in rational design enable precise genetic modifications to enhance safety and immunogenicity. This review highlights key molecular strategies advancing next-generation LAIV development and their potential to accelerate the production of safer, more effective vaccines against seasonal and pandemic influenza.

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合成生物学启发研制减毒流感活疫苗。

流感减毒活疫苗（LAIVs）提供强大的交叉保护免疫，但传统上是经验开发的，并且与安全问题有关。合理设计的最新进展使精确的基因修饰能够提高安全性和免疫原性。本综述强调了推进下一代LAIV开发的关键分子策略，以及它们在加速生产更安全、更有效的季节性和大流行性流感疫苗方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.