Immunoregulator multitasking in neurons is not just a WHIM.

IF 15 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-08-20 DOI:10.1016/j.neuron.2025.07.027

Philip M Murphy

引用次数: 0

Abstract

Distinguishing direct from indirect mechanisms is often difficult in multisystem genetic conditions. In this issue of Neuron, Demenego et al.¹ report that cerebellar malformation and dysfunction in WHIM syndrome immunodeficiency result from direct effects of hyperfunctional CXCR4 in neurons.

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神经元中的免疫调节多任务处理不仅仅是一时兴起。

在多系统遗传条件下，区分直接机制和间接机制往往是困难的。Demenego等人在本期《神经元》杂志上报道，WHIM综合征免疫缺陷的小脑畸形和功能障碍是由神经元中功能亢进的CXCR4直接作用的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.