Anti-Bredt-Like Triterpenoids from Mycelial Cultures of the Edible Mushroom Oudemansiella cf. canarii

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-04 DOI:10.1021/acs.orglett.5c03296

Malipan Sappan, Panida Chinthanom, Vanicha Vichai, Thitiya Boonpratuang, Teera Chantarojsiri* and Masahiko Isaka*,

引用次数: 0

Abstract

Sixteen undescribed triterpene glycosides, oudecanarins A–P (1–16), were isolated from cultures of basidiomycete Oudemansiella cf. canarii TBRC-BCC 85371. Oudecanarins A–G (1–7) contain a bicyclo[4.3.1]decene system bearing the bridgehead double bond as a DE ring of pentacyclic triterpene. The unique carbon skeleton was confirmed by the X-ray crystallographic analysis of oudecanarin B (2). The proposed plausible late-stage biosynthetic pathway for oudecanarin A (1) was supported by chemical conversion experiments.

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食用菌Oudemansiella cf. canarii菌丝体培养物中抗布雷特样三萜。

从担子菌Oudemansiella c.c anarii TBRC-BCC 85371培养物中分离到16个未描述的三萜苷，分别为oudecanarins A-P（1-16）。二烷基萘苷a - g（1-7）含有一个双环[4.3.1]癸烯体系，其桥头堡双键为五环三萜的DE环。独特的碳骨架被x射线晶体学分析证实(2)。通过化学转化实验，证实了乌地楠素A(1)的后期生物合成途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.