A Comprehensive Bibliometric and Visual Analysis of EGR1 in Cardiovascular Disease.

IF 2.5 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biotechnology Pub Date : 2025-08-29 DOI:10.1007/s12033-025-01493-7

Na Dong, Hongmei Yue

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引用次数: 0

Abstract

Early Growth Response 1 (EGR1) is a crucial transcription factor that regulates diverse cellular processes, including growth, differentiation, proliferation, inflammation, apoptosis, and autophagy. It plays a vital role in maintaining cardiac homeostasis and is deeply implicated in the pathological mechanisms leading to cardiomyocyte death, making it a promising therapeutic target for cardiovascular diseases. To better understand the research landscape of EGR1 in this context, we conducted a bibliometric analysis using data from the Web of Science Core Collection (WoSCC) covering the period from 2014 to 2024, retrieved on 31 December 2024. A total of 2,112 publications related to EGR1 were identified, of which 173 specifically addressed cardiovascular disease and were published across 126 journals. Global research output on this topic has shown fluctuating growth over the past decade, with China contributing the most publications and citations. The Institut national de la santé et de la recherche médicale (Inserm) emerged as the most productive institution. Zhang Y authored the highest number of papers, while Wang J received the most citations. Scientific Reports was the most prolific journal, whereas the Journal of Biological Chemistry was the most influential in terms of citation metrics. Keyword co-occurrence and cluster analysis revealed major research themes such as apoptosis, inflammation, oxidative stress, angiogenesis, and autophagy. These findings provide a comprehensive overview of EGR1-related cardiovascular research and offer a valuable reference for future investigations into its mechanisms and therapeutic potential.

查看原文本刊更多论文

心血管疾病中EGR1的综合文献计量学和视觉分析。

早期生长反应1 （EGR1）是调节多种细胞过程的关键转录因子，包括生长、分化、增殖、炎症、凋亡和自噬。它在维持心脏稳态中起着至关重要的作用，并与导致心肌细胞死亡的病理机制密切相关，使其成为心血管疾病的有希望的治疗靶点。为了更好地了解EGR1在这一背景下的研究格局，我们对Web of Science Core Collection （WoSCC）中2014 - 2024年的数据进行了文献计量分析，检索时间为2024年12月31日。共确定了2112篇与EGR1相关的出版物，其中173篇专门针对心血管疾病，发表在126个期刊上。在过去十年中，关于这一主题的全球研究产出呈现波动增长，其中中国的出版物和引用最多。国家青年和青年研究所（Institut de la sant et de la research che imacdiale）成为最具生产力的机构。张颖的论文数量最多，王杰的被引次数最多。《科学报告》是最多产的期刊，而《生物化学杂志》在引用指标方面最有影响力。关键词共现和聚类分析揭示了凋亡、炎症、氧化应激、血管生成和自噬等主要研究主题。这些发现为egr1相关的心血管研究提供了全面的综述，并为进一步研究其机制和治疗潜力提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.