Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025.

IF 7.8 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2025-08-01 DOI:10.2807/1560-7917.ES.2025.30.34.2500605

Neta S Zuckerman, Yaniv Lustig, Danit Sofer, Lester M Shulman, Leah Weiss, Rinat Vasserman, Reut Gabai, Keren Friedman, Hagar Eliyahu, Noa Bar-Liss, Tatyana Kushnir, Ira Aguvaev, Tal Butensky, Daniel Avhar, Alex Aydenzon, Oran Erster, Itay Bar-Or, Merav Weil

引用次数: 0

Abstract

We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case. Whole genome sequencing revealed a strong genetic link between the Sabin-like poliovirus type 1 variant from the case and pre-VDPV1 and VDPV1 isolated from environmental samples collected in October 2024-April 2025, mostly in Jerusalem. Early detection was made possible by Israel's robust environmental surveillance and advanced sequencing technologies, enabling a rapid public health response.

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在以色列，2024年至2025年，在VDPV1出现之前，早期发现与急性弛缓性脊髓灰质炎病例相关的循环疫苗前衍生1型脊髓灰质炎病毒（VDPV1前）变体。

我们报告了以色列循环疫苗衍生脊髓灰质炎病毒1型（cVDPV1）暴发的出现和演变，与疫苗相关的麻痹性脊髓灰质炎病例有关。全基因组测序显示，来自该病例的sabin样脊髓灰质炎病毒1型变体与从2024年10月至2025年4月（主要在耶路撒冷）收集的环境样本中分离的前VDPV1和VDPV1之间存在很强的遗传联系。以色列强大的环境监测和先进的测序技术使早期发现成为可能，从而能够迅速作出公共卫生反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.