{"title":"Bacterial Extracellular Vesicles: Emerging Regulators in the Gut-Organ Axis and Prospective Biomedical Applications.","authors":"Bingqi Zhang, Mingyan Liu, Lingxin Jiang, Ziqiu Chen, Wei Tian, Kaidi Li, Bin Yu, Wenlan Zhang, Sirui Li, Yuzhu Zhou, Huhu Li, Yilan Xu, Yongna Dai","doi":"10.1007/s00284-025-04474-w","DOIUrl":null,"url":null,"abstract":"<p><p>The critical role of gut microbiota and their metabolites in host health has been extensively studied. In recent years, bacterial extracellular vesicles (BEVs) released by gut bacteria have gained increasing attention as carriers of bioactive substances and signaling molecules. This review systematically summarizes the biogenesis of BEVs and their potential regulatory roles in gut-organ axis diseases, including disorders of the central nervous system, kidneys, liver, bones, lungs, cardiovascular system, and metabolism. Additionally, we explore the prospects and applications of BEVs in disease diagnosis and prevention. This paper provides a novel perspective on the multifaceted roles of BEVs in host health and disease and lays a theoretical foundation for the development of BEV-based diagnostic and therapeutic tools in future.</p>","PeriodicalId":11360,"journal":{"name":"Current Microbiology","volume":"82 10","pages":"486"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00284-025-04474-w","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The critical role of gut microbiota and their metabolites in host health has been extensively studied. In recent years, bacterial extracellular vesicles (BEVs) released by gut bacteria have gained increasing attention as carriers of bioactive substances and signaling molecules. This review systematically summarizes the biogenesis of BEVs and their potential regulatory roles in gut-organ axis diseases, including disorders of the central nervous system, kidneys, liver, bones, lungs, cardiovascular system, and metabolism. Additionally, we explore the prospects and applications of BEVs in disease diagnosis and prevention. This paper provides a novel perspective on the multifaceted roles of BEVs in host health and disease and lays a theoretical foundation for the development of BEV-based diagnostic and therapeutic tools in future.
期刊介绍：
Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment.
Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas:
physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.
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