A decade of migrasome research: biogenesis, physiological functions, and disease implications

IF 25.9 1区 生物学 Q1 CELL BIOLOGY
Jinqiang Yu, Li Yu
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引用次数: 0

Abstract

Since their first report a decade ago, our understanding of migrasomes — specialized organelles initially identified in migrating cells—has advanced considerably. Researchers have elucidated key aspects of migrasome biology, including the mechanisms of their biogenesis, their roles in cellular physiology, and their implications in various diseases. Concurrently, the development of a robust toolkit for migrasome analysis has transformed these structures from mere microscopy curiosities into central players in an emerging field with significant impact on cell biology, developmental biology, immunology, and disease pathology. This review provides a comprehensive summary of current insights into migrasome biology, with a particular focus on the molecular mechanisms governing their formation and their established cellular and physiological functions. In addition, we highlight the current challenges and unresolved questions that continue to shape and propel future research in this exciting area of study.

Abstract Image

十年来偏头痛研究:生物发生、生理功能和疾病影响。
自从十年前他们的第一份报告以来,我们对迁移体(最初在迁移细胞中发现的特化细胞器)的理解有了很大的进步。研究人员已经阐明了迁移体生物学的关键方面,包括它们的生物发生机制,它们在细胞生理学中的作用,以及它们在各种疾病中的意义。同时,一个强大的迁移体分析工具包的发展已经将这些结构从单纯的显微镜好奇心转变为对细胞生物学、发育生物学、免疫学和疾病病理学产生重大影响的新兴领域的核心参与者。本文综述了目前对迁移体生物学的深入研究,重点介绍了迁移体形成的分子机制及其已建立的细胞和生理功能。此外,我们还强调了当前的挑战和未解决的问题,这些问题将继续塑造和推动这一令人兴奋的研究领域的未来研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Research
Cell Research 生物-细胞生物学
CiteScore
53.90
自引率
0.70%
发文量
2420
审稿时长
2.3 months
期刊介绍: Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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