Contribution of the major histocompatibility complex (MHC) B locus-based genetic resistance to multiple strains of infectious bursal disease virus.

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2025-09-16 DOI:10.1080/03079457.2025.2547582

Julia R Blakey, Maricarmen García, Daral J Jackwood, Rami A Dalloul, Sujit K Mohanty, John R Dunn

引用次数: 0

Abstract

Research highlights: The host B locus and the IBDV pathotype impact development of clinical disease.The host B locus has significant effects on IBDV-induced early mortality.The host B locus has no significant effect on IBDV-induced bursal damage.

查看原文本刊更多论文

主要组织相容性复合体（MHC） B基因座对多种传染性法氏囊病病毒株的遗传抗性的贡献

利用7系主要组织相容性复合体(MHC)-B同源特异性病原体（SPF）鸡和2系B单倍型相似但非MHC基因不同的非B同源SPF鸡，研究了B位点在感染性法氏囊病（IBD）发病中的作用。在最初的实验中，在28日龄时用变异型传染性法氏囊病病毒（IBDV） AL-2株、经典IBDV株STC或非常毒力（vv） IBDV株rA攻毒鸡。在整个7天的感染过程中，通过评估生存能力和法氏囊病变评分的组织病理学分析来评估IBD严重程度。后续研究调查了不同STC攻击剂量对IBD发展的影响。结果表明，IBDV的攻毒菌株对基于B位点的遗传抗性有较大的影响。以MHC-B基因鸡系B*13和B*19最易感，vvIBDV攻毒后鸡的存活率和法氏囊病变差异最显著。基于存活能力，B*19鸡系在高剂量（105 EID50）攻毒后最易感。用变异菌株AL-2攻毒后，各组间的存活率没有差异。根据这些鸡系的结果，基于B基因座的IBDV遗传抗性主要与感染早期的存活有关，与法氏囊损伤和法氏囊淋巴细胞耗损的关系很小。基于非b基因座的遗传差异也对早期IBDV感染期间的生存有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.