Pathogenicity disparities between two avian reovirus strains of the same genetic cluster.

IF 2.2 2区农林科学 Q1 VETERINARY SCIENCES

Avian Pathology Pub Date : 2025-09-19 DOI:10.1080/03079457.2025.2551119

Edit Kovács, Renáta Varga-Kugler, Zalán Homonnay, Tímea Tatár-Kis, Tamás Mató, Szilvia Marton, Krisztián Bányai, István Kiss

引用次数: 0

Abstract

Research highlights: ARV strains of the same genotype had distinct pathogenic and transmission traits.LambdaC, muB, and sigmaC genes made a difference.SigmaC-based genotyping obscures pathogenicity differences.

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同一基因簇的两种禽呼肠孤病毒株致病性差异。

根据sigmaC编码区的部分序列，研究人员比较了来自临床感染禽群的两种禽呼肠孤病毒（A和B）的分子和致病性，包括宿主内传播和宿主间传播能力、显微病变和不同器官的病毒载量。菌株B造成10%的死亡率和更严重的肝脏和心脏损伤，传播到接触动物的速度较慢。菌株A传播速度快，致病性低，无致死率。全基因组序列分析显示，这两种菌株具有嵌合性，基因片段与疫苗样或疫苗来源有关。除了lambdaC， muB和sigmaC基因外，还发现了高核苷酸和氨基酸序列的一致性。菌株B的LambdaC基因归属于疫苗株，而菌株A的分支归属于野生呼肠孤病毒。菌株B的muB基因与一些匈牙利和中国鸡源菌株和野鸡源重组菌株的等位基因相似。尽管S1基因相似，但菌株表现出不同的致病性和传播能力。这些发现表明，基于sigmac的基因分型可以掩盖致病性差异。全基因组测序和鉴定对于鉴定致病性分子标记至关重要，并通过精心整理的序列和标准化的致病性数据库加以加强。研究表明，同一基因型的ARV毒株具有不同的致病和传播特性。(LambdaC， muB和sigmaC基因起了作用。基于sigmac的基因分型模糊了致病性差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Avian Pathology 农林科学-兽医学

CiteScore

4.50

自引率

10.70%

发文量

审稿时长

1 months

期刊介绍： Avian Pathology is the official journal of the World Veterinary Poultry Association and, since its first publication in 1972, has been a leading international journal for poultry disease scientists. It publishes material relevant to the entire field of infectious and non-infectious diseases of poultry and other birds. Accepted manuscripts will contribute novel data of interest to an international readership and will add significantly to knowledge and understanding of diseases, old or new. Subject areas include pathology, diagnosis, detection and characterisation of pathogens, infections of possible zoonotic importance, epidemiology, innate and immune responses, vaccines, gene sequences, genetics in relation to disease and physiological and biochemical changes in response to disease. First and subsequent reports of well-recognized diseases within a country are not acceptable unless they also include substantial new information about the disease or pathogen. Manuscripts on wild or pet birds should describe disease or pathogens in a significant number of birds, recognizing/suggesting serious potential impact on that species or that the disease or pathogen is of demonstrable relevance to poultry. Manuscripts on food-borne microorganisms acquired during or after processing, and those that catalogue the occurrence or properties of microorganisms, are unlikely to be considered for publication in the absence of data linking them to avian disease.