Effect of pH on the Kinetics of Cysteine-to-Cystine Conversion in Thin Films Formed by ESI Microdroplet Deposition

IF 2.7 2区化学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of the American Society for Mass Spectrometry Pub Date : 2025-08-29 DOI:10.1021/jasms.5c00195

Marta Managò, , , Chiara Salvitti, , , Anna Troiani, , , Alessia Di Noi, , , Andreina Ricci, , and , Federico Pepi*,

引用次数: 0

Abstract

The oxidation of cysteine to cystine was investigated in aqueous thin films generated by the deposition of electrospray ionization (ESI) microdroplets. The confined volume of the thin film promotes the reaction, resulting in up to 80% conversion of cysteine to cystine at a thin film temperature of 40 °C. The pH of the solution is a critical parameter, influencing both the yield and the kinetics of the reaction. Strong reaction acceleration factors in thin film with respect to the bulk were measured.

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pH对ESI微滴沉积薄膜中半胱氨酸到胱氨酸转化动力学的影响。

研究了半胱氨酸在电喷雾微滴沉积制备的半胱氨酸薄膜中的氧化反应。薄膜的有限体积促进了反应，在40℃的薄膜温度下，半胱氨酸转化为胱氨酸的转化率高达80%。溶液的pH值是影响反应收率和动力学的关键参数。测定了薄膜中相对于体积的强反应加速因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Society for Mass Spectrometry 化学-分析化学

CiteScore

5.50

自引率

9.40%

发文量

257

审稿时长

1 months

期刊介绍： The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives