Differentiation of cisplatin uptake amid the population of cancer cells – how to 'crack this nut' using single-cell ICP-MS?

Abstract

A versatile tool to unravel the uptake diversity of a front-line anticancer drug, cisplatin, within a cancer cell population is proposed herein based on single-cell inductively coupled plasma mass spectrometry. An interested researcher is provided with the tutorial to help adapt such cutting-edge methodology and know-how to reliable data processing.