{"title":"Recurrent Acinic Cell Carcinoma of Parotid Gland Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report","authors":"Anju Khairwa, Priya Suneja, Preeti Diwaker","doi":"10.1002/dc.25505","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Acinic cell carcinoma (ACC) is a rare malignant tumor of the head and neck region. It accounts for 12.4%–17.4% of parotid gland malignancies and approximately 3.4% of all salivary gland tumors. ACC is a low-grade salivary gland malignancy that predominantly affects females. In some cases, ACC can undergo high-grade transformation (HGT), resulting in more aggressive behavior. Here, we present a rare case of recurrent Acinic cell carcinoma with aggressive features and high-grade cytomorphology—including increased cellularity, papillary and singly scattered cells, high nuclear-to-cytoplasmic (N:C) ratio, coarse chromatin, and single-cell necrosis in the background—diagnosed via fine-needle aspiration cytology (FNAC) and further confirmed by histopathology and immunohistochemistry. This case can be categorized as ACC recurrence associated with high-grade transformation (HGT).</p>\n </div>","PeriodicalId":11349,"journal":{"name":"Diagnostic Cytopathology","volume":"53 10","pages":"E190-E193"},"PeriodicalIF":1.0000,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dc.25505","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Acinic cell carcinoma (ACC) is a rare malignant tumor of the head and neck region. It accounts for 12.4%–17.4% of parotid gland malignancies and approximately 3.4% of all salivary gland tumors. ACC is a low-grade salivary gland malignancy that predominantly affects females. In some cases, ACC can undergo high-grade transformation (HGT), resulting in more aggressive behavior. Here, we present a rare case of recurrent Acinic cell carcinoma with aggressive features and high-grade cytomorphology—including increased cellularity, papillary and singly scattered cells, high nuclear-to-cytoplasmic (N:C) ratio, coarse chromatin, and single-cell necrosis in the background—diagnosed via fine-needle aspiration cytology (FNAC) and further confirmed by histopathology and immunohistochemistry. This case can be categorized as ACC recurrence associated with high-grade transformation (HGT).
期刊介绍：
Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.
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