Glucagon-like peptide-1 receptor agonists are associated with a lower risk of peptic ulcer disease: a nationwide cohort study

IF 12 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Clinical Gastroenterology and Hepatology Pub Date : 2025-08-25 DOI:10.1016/j.cgh.2025.08.015

Philippa Seika MD, Jocelyn Chang BS, Su Min Hong BS, Sarah Ballou MD, Vikram Rangan MD, Chethan Ramprasad MD, Johanna Iturrino MD, Christian Denecke MD, Anthony Lembo MD, Judy Nee MD, Subhash Kulkarni PhD, Trisha Pasricha MD MPH

引用次数: 0

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are prescribed for type 2 diabetes mellitus (T2DM) to improve glycemic control and lower cardiovascular risk. While the impact of GLP-1RAs on gastrointestinal (GI) motility has been characterized, their association with mucosal damage, such as in peptic ulcer disease (PUD), has received little attention.

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胰高血糖素样肽-1受体激动剂与消化性溃疡疾病风险降低相关：一项全国性队列研究

胰高血糖素样肽-1受体激动剂（GLP-1 RAs）是2型糖尿病（T2DM）的处方，以改善血糖控制和降低心血管风险。虽然GLP-1RAs对胃肠道（GI）运动的影响已经被表征，但它们与粘膜损伤（如消化性溃疡疾病（PUD））的关联却很少受到关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Gastroenterology and Hepatology 医学-胃肠肝病学

CiteScore

16.90

自引率

4.80%

发文量

903

审稿时长

22 days

期刊介绍： Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion. As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.