A Brief Report on Identification of Splice Variants in an In Vitro 3D Spheroid Model for Differentiated Hepatocellular Carcinoma

Abstract

Hepatocellular carcinoma (HCC) represents the major form of primary liver cancer. Alternative splicing events (ASEs) are critical to generating mRNA splice variants that can dictate cell fate during HCC development. We report different ASEs in a 3D in vitro HCC spheroid model. This short study serves as a template to design functional studies to target different splicing events in different subtypes of hepatocellular carcinoma.