How squeezed cells remember their shape to migrate efficiently

IF 18.4 1区物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY

Nature Physics Pub Date : 2025-08-28 DOI:10.1038/s41567-025-02984-9

引用次数: 0

Abstract

Cells migrating through narrow spaces in their environment undergo repeated shape changes to pass through tight constrictions. Epithelial cells retain a memory of past confinement, allowing them to maintain a polarized, compact morphology that enhances future migration through narrow gaps. This memory is mechanically encoded in the actin cortex.

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被挤压的细胞如何记住它们的形状，从而有效地迁移

细胞在环境中的狭窄空间中迁移，通过反复的形状变化来通过狭窄的空间。上皮细胞保留了过去禁闭的记忆，使它们保持极化、紧凑的形态，从而增强了未来通过狭窄间隙的迁移。这种记忆被机械地编码在肌动蛋白皮层中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Physics 物理-物理：综合

CiteScore

30.40

自引率

2.00%

发文量

349

审稿时长

4-8 weeks

期刊介绍： Nature Physics is dedicated to publishing top-tier original research in physics with a fair and rigorous review process. It provides high visibility and access to a broad readership, maintaining high standards in copy editing and production, ensuring rapid publication, and maintaining independence from academic societies and other vested interests. The journal presents two main research paper formats: Letters and Articles. Alongside primary research, Nature Physics serves as a central source for valuable information within the physics community through Review Articles, News & Views, Research Highlights covering crucial developments across the physics literature, Commentaries, Book Reviews, and Correspondence.