Unraveling lymphoma-induced immune senescence

IF 44.5 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2025-08-21 DOI:10.1016/j.ccell.2025.07.009

Patrizia Mondello, Stephen M. Ansell

引用次数: 0

Abstract

B cell lymphomas arise from mutations that disrupt normal germinal center B cell programs and promote a microenvironment that fosters aberrant proliferation and immune escape. In this issue of Cancer Cell, Hesterberg et al. show that lymphoma accelerates T cell aging by transcriptional and epigenetic reprogramming that mirrors physiological aging.

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解开淋巴瘤引起的免疫衰老

B细胞淋巴瘤是由突变引起的，这些突变破坏了正常的生发中心B细胞程序，促进了一个微环境，促进了异常增殖和免疫逃逸。在这一期的《癌细胞》杂志上，Hesterberg等人发现淋巴瘤通过转录和表观遗传重编程加速T细胞衰老，这反映了生理衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.