A model for propagation of RNA structural memory through biomolecular condensates

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-08-20 DOI:10.1038/s41556-025-01736-4

Chen Cai, Jiancheng Yu, Xudong Zhang, Tong Zhou, Qi Chen

引用次数: 0

Abstract

We hypothesize that stress-induced RNA structural changes, stabilized by RNA-binding proteins in biomolecular condensates, propagate via conformational catalysis in a prion-like manner across generations. Our model suggests that RNA structure encodes heritable memory, and its roles should be explored in epigenetic inheritance, evolutionary adaptation and disease.

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RNA结构记忆通过生物分子凝聚体传播的模型

我们假设，应力诱导的RNA结构变化，由生物分子凝聚物中的RNA结合蛋白稳定，通过朊病毒样的构象催化在几代之间传播。我们的模型表明，RNA结构编码可遗传记忆，其在表观遗传、进化适应和疾病中的作用有待探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology