Ketogenic Diet as Protection for Deprescribing Antipsychotics

IF 4.8 1区医学 Q1 PSYCHIATRY

Schizophrenia Bulletin Pub Date : 2025-08-23 DOI:10.1093/schbul/sbaf127

Jann E Schlimme

引用次数: 0

Abstract

People with schizophrenia or schizoaffective disorder are almost always treated with continued use of antipsychotics. Tapering of antipsychotics is very often associated with a recurrence of symptoms within a year. This applies particularly to the final steps of reduction from very small doses. Ketosis seems to offer protection against psychotic relapses in these final steps. I report a case series that supports this thesis. Two effects of antipsychotics that disappear after discontinuation of the medication and can be replaced by ketosis could possibly be responsible for this: effects on the mesolimbic system against the background of insufficient GABAergic inhibition in the prefrontal cortex and mesolimbic system; effects on the microglia against the background of increased unspecific neuroinflammation.

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生酮饮食对抗精神病药物处方的保护作用

患有精神分裂症或分裂情感性障碍的人几乎总是持续使用抗精神病药物进行治疗。抗精神病药物的逐渐减少通常与一年内症状的复发有关。这尤其适用于从很小剂量开始减少的最后步骤。酮症似乎在这些最后的步骤中提供了防止精神病复发的保护。我报告了一个支持这一论点的案例系列。抗精神病药物在停药后消失并可被酮症所取代的两种作用可能是造成这一现象的原因：在前额叶皮层和中边缘系统gaba能抑制不足的背景下对中边缘系统的影响；非特异性神经炎症增加背景下对小胶质细胞的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Bulletin 医学-精神病学

CiteScore

11.40

自引率

6.10%

发文量

163

审稿时长

4-8 weeks

期刊介绍： Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.