B-cell antigen presentation in central nervous system autoimmunity

IF 5.8 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-08-25 DOI:10.1016/j.coi.2025.102647

Carson E Moseley , Joseph J Sabatino Jr , Scott S Zamvil

引用次数: 0

Abstract

The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG⁺ neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disorder (MOGAD) has expanded our appreciation of the contribution of B cells in multiple CNS autoimmune diseases. B cells have multiple functions in the initiation and propagation of CNS autoimmunity that extend beyond autoantibody production, including bidirectional interactions with T cells via B-cell antigen presentation. A deeper understanding of the cooperation between B cells and T cells in MS, NMO, and MOGAD should permit the development of more effective therapies across CNS autoimmune disorders.

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b细胞抗原在中枢神经系统自身免疫中的表现

抗cd20单克隆抗体在多发性硬化症（MS）中的成功临床试验最初强调了B细胞在中枢神经系统（CNS）自身免疫中的作用。MS以及水通道蛋白4 (AQP4)-IgG+视神经脊髓炎（NMO）和髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）的研究扩大了我们对B细胞在多种中枢神经系统自身免疫性疾病中的作用的认识。B细胞在CNS自身免疫的启动和传播中具有多种功能，这些功能超出了自身抗体的产生，包括通过B细胞抗原呈递与T细胞的双向相互作用。更深入地了解B细胞和T细胞在MS、NMO和MOGAD中的合作，将有助于开发更有效的治疗中枢神经系统自身免疫性疾病的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

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